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Abstract
I have a long-standing interest in investigating cellular behaviors and interactions in complex environments. My PhD studies in the Joyce Lab focused on uncovering the transcriptional regulation and developmental ontogeny of tumor-associated macrophages in brain tumors. I employed computational tools and a number of different genetic lineage tracing and tumor models with complementary analysis on patient-derived specimen. As I studied the functions of myeloid cells in disease, I became increasingly interested in the epigenetic mechanisms regulating their development, and how these processes can be co-opted in leukemia.
In the fall of 2016, I began my postdoctoral work with Dr. Ross Levine, setting out to model clonal evolution and clone-clone interactions in myeloid leukemias. In a recently published co-first author study in Nature, I developed an analytical framework for the analysis of single cell DNA sequencing, resulting in a comprehensive understanding of the genetic architecture of myeloid malignancy. I further developed a series of novel murine genetic tools to evaluate mutation order and oncogene-dependency using multiple, orthogonally inducible recombinases. These studies have revealed distinct patterns disease penetrance and immunophenotype depending upon the cooperating mutations.
Education
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Years
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Degree
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2006-2010
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B.A. Vanderbilt University
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2010-2016
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Ph.D Cancer Biology, Gerstner Sloan Kettering Graduate Program
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Positions and Employment
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Years
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Position
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2007 - 2010
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Undergraduate Researcher, Vanderbilt University, Nashville, TN
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2009 - 2010
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Teaching Assistant, Vanderbilt University, Nashville, TN
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2010 - 2016
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Graduate Student, Gerstner Sloan Kettering Cancer Center, New York, NY
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2016 -
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Research Scholar, MSKCC, New York, NY
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2016 - 2017
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Teaching Assistant - Computational Biology, Gerstner Sloan Kettering Graduate Program, New York, NY
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2017 - 2019
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Instructor - Quantitative Biology, Gerstner Sloan Kettering Graduate Program, New York, NY
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Publications
Full list of publications can be found here
Fellowships and Honors
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Year
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2008-2010
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Summer Undergraduate Research Fellow, Vanderbilt University
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2010
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Undergraduate Research Award, Vanderbilt University
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2010-2016
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Grad into Med Initiative, HHMI
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2010
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cum laude, Vanderbilt University
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2011
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Geoffrey Beene Fellowship, Gerstner Sloan Kettering Graduate Program
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2012-2016
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NRSA F31, National Cancer Institute
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2017-2020
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Sohn Fellow, Damon Runyon Cancer Research Foundation
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2020-Present
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K99/R00 Pathway to Independece Award, National Cancer Institute
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Other Experience and Professional Memberships
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Years
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2010 - 2016
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Graduate Student Member, New York Academy of Sciences
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2012
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Attendee, Statistical Analysis of Genomics Data - Cold Spring Harbor Labs
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Presentations and Seminars
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Date
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Presentation Title
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Venue
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June 23rd, 2021
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Genetic and genomic approaches to modeling clonal evolution in myeloid malignancy.
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Illumina webinar series.
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September 24th, 2021
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Single cell profiling delineates clonal trajectories in myeloid malignancies.
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MSKCC Postdoctoral Research Symposium
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May 15th 2016
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Convocation speaker (selected by peers)
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MSKCC
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March 2nd, 2021
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Modeling subclonal FLT3 mutations in acute myeloid leukemia.
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NYC leukemia working group
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Patents
- Compositions and methods for treatment of glioma (PCT/US2016/031431). Daniela F Quail, Johanna A Joyce, Robert L Bowman. This patent covers the dual targeting of CSF-1R inhibition and PI3-Kinase inhibition, or IGF-1R inhibitors, in the treatment of glioblastoma multiforme and other brain malignancies. The rationale is that CSF-1R targeting results in altered tumor associated macrophage function which engenders a dependency in tumor cells upon macrophage-derived IGF1 for survival. November 17th, 2016
- Inhibition of colony stimulating factor-1 receptor signaling for the treatment of brain cancer (PCT/US2013/036628). Johanna A Joyce, Robert L Bowman. This patent covers the utility of a gene expression signature in predicting responsiveness to CSF-1R inhibitor therapy in glioblastoma multiforme and other brain malignancies. October 24th, 2013
Research Grants
- PI: K99CA248460-01, NIH Pathway to Independence Award (Parent K99/R00). Interrogating oncogene-dependency and mutation order in FLT3 mutant AML. 04/01/20-03/31/22
- Co-I: R01CA237213, NCI. Mechanisms of UV-mediated melanoma development. 09/04/202-05/31/2025. ($84,745 of $1,774,506)
- PI: DR-SG 22-17, Damon Runyon-Sohn Cancer Research Foundation. Interrogating subclonal architecture and functional contributions of mutation order in AML. 07/01/17-03/31/20
- PI: F31 CA167863-01-04. NCI. The Roles of Microglia and Macrophage Populations in the Glioma Microenvironment. 09/18/12–09/17/16
Scientific Leadership and Teaching
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Gerstner Sloan Kettering Core Course - Computational Biology
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Instructor
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2017-2019
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Weill Cornell Medical College – Quantitative Biology
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Teaching assistant
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Fall 2015
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MSKCC Career Services – Data Carpentry Workshop
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Teaching assistant
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August 2015
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MSKCC Summer Undergraduate Research Program
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Graduate Mentor
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Fall 2014
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Gerstner Sloan Kettering Core Course
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Teaching assistant
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October 2014
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Vanderbilt University – Introduction to Biology
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Teaching assistant
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2009-2010
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